History
The first use for vitamin E as a therapeutic agent was conducted in 1938 by Widenbauer. Widenbauer used wheat germ oil supplement on 17 premature newborn infants suffering from growth failure. 11 out of the original 17 patients recovered and were able to resume normal growth rates.
In 1945, Drs. Evan V. Shute and Wilfred E. Shute, two brothers of Ontario, Canada, published the first monograph arguing that megadoses of vitamin E can slow down and even reverse the development of atherosclerosis. Peer-reviewed publications soon followed.
The same research team also demonstrated, in 1946, that alpha tocopherol improved impaired capillary permeability and low platelet counts in experimental and clinical thrombocytopenic purpuras.
Later on, in 1948, while conducting experiments on alloxan effects on rats, Gyorge and Rose noted that the rats receiving tocopherol supplements suffered from less hemolysis than those that did not receive tocopherol. In 1949, Gerloczy administered all-rac-α-tocopheryl acetate to prevent and cure edema. Methods of administration used were both oral, that showed positive response, and intramuscular, which did not show a response. This early investigative work on the benefits of vitamin E supplementation was the gateway to curing the vitamin E deficiency caused hemolytic anemia described during the 1960s. Since then, supplementation of infant formulas with vitamin E has eradicated this vitamin’s deficiency as a cause for hemolytic anemia.
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