Visceral Leishmaniasis - Prevention

Prevention

There is no vaccine for this disease as of 2012.

On February 2012, the nonprofit Infectious Disease Research Institute launched the world’s first clinical trial of the visceral leishmaniasis vaccine. The vaccine is a recombinant form of two fused Leishmania parasite proteins with an adjuvant. Two phase 1 clinical trials with healthy volunteers are to be conducted. The first one takes place in Washington (state) and is followed by a trial in India.


The use of lipid complexed amphotericin b to treat visceral leishmaniasis was pioneered by Henry Murray, MD, who recognized that infected macrophages would engulf the lipid complexes, liberating amphotericin at the point of infection while minimizing untoward systemic side effects, e.g. renal distal tubule damage. Doctor Murray's work resulted in a paradigm shift in the treatment of and control of this parasitic disease in India.

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