VISA (gene)

VISA (gene)

Identifiers Symbols MAVS; CARDIF; IPS-1; IPS1; VISA External IDs OMIM: 609676 MGI: 2444773 HomoloGene: 17004 GeneCards: MAVS Gene

Gene Ontology
Molecular function	• signal transducer activity • protein binding • protein kinase binding • CARD domain binding
Cellular component	• mitochondrial outer membrane • peroxisomal membrane • integral to membrane • mitochondrial membrane
Biological process	• positive regulation of protein phosphorylation • activation of innate immune response • positive regulation of defense response to virus by host • signal transduction • virus-host interaction • negative regulation of type I interferon production • positive regulation of interferon-alpha production • positive regulation of interferon-beta production • positive regulation of interleukin-8 production • positive regulation of tumor necrosis factor production • positive regulation of protein import into nucleus, translocation • defense response to bacterium • positive regulation of transcription factor import into nucleus • positive regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of viral genome replication • innate immune response • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • defense response to virus • positive regulation of type I interferon-mediated signaling pathway • cellular response to exogenous dsRNA • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of IP-10 production • regulation of peroxisome organization
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 57506 228607 Ensembl ENSG00000088888 ENSMUSG00000037523 UniProt Q7Z434 Q8VCF0 RefSeq (mRNA) NM_001206491 NM_001206382 RefSeq (protein) NP_001193420 NP_001193311 Location (UCSC) Chr 20:
3.83 – 3.85 Mb Chr 2:
131.23 – 131.25 Mb PubMed search

Mitochondrial antiviral-signaling protein (MAVS) is a protein that in humans is encoded by the MAVS gene. The protein is also known by the names VISA (virus-induced signaling adapter), IPS-1 and Cardif. Aggregated MAVS form protease resistant prion-like aggregates that activate IRF3 dimerization.