Viral Bioinformatics Resource Center - Organization of The VBRC Database

Organization of The VBRC Database

The VBRC database stores viral bioinformatic data on three levels:

  1. Whole genomes. This level contains information about the virus species or isolate and its entire genomic sequence.
  2. Annotated genes. This level contains all the predicted ORFs (open reading frames) in a particular virus genome, together with their DNA and (translated) protein sequences.
  3. Ortholog groups (families). This level is a distinguishing feature of the VBRC database. Each annotated gene, after it has been entered into the database, is subjected to BLASTP searching against all other genes already in the database. Based on the search results, it is either assigned to a pre-existing ortholog group or placed in a newly created ortholog group of its own. The goal of this level is to "allow for quick comparison of similar genes across a given virus family."

Read more about this topic:  Viral Bioinformatics Resource Center

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