Vesicular-tubular Cluster

vesicular-tubular cluster (VTC), discovered in 1984 also referred to as the ER-Golgi intermediate compartment (or ERGIC), is an organelle in eukaryotic cells. This compartment mediates trafficking between the endoplasmic reticulum and Golgi complex, facilitating the sorting of cargo. The compartment was first defined as the location within the cell of the mannose-binding membrane lectin called ERGIC-53.

In mammalian organisms, COPII vesicles that have budded from exit sites in the endoplasmic reticulum lose their coats and fuse to form the vesicular-tubular cluster (VTC). Retrieval (or retrograde) transport in COPI vesicles returns many of the lost ER resident proteins back to the endoplasmic reticulum. Forward (or anterograde) transport moves the VTC contents to the cis-Golgi network, the receiving face of the Golgi complex. This process is thought to occur by one of two processes. One is known as cisternal maturation where the VTC simply matures into the cis-Golgi network. In another COPI vesicular transport moves VTC material to the receiving face of the Golgi apparatus. A fuller explanation of the two processes is described (see Golgi complex). Evidence exists for both processes and it may be that both occur simultaneously in cells.