Vesicle may refer to:
- In cellular biology or chemistry
- Vesicle (biology), a supramolecular assembly of lipid molecules, like a cell membrane
- Synaptic vesicle
- In human embryology
- Auditory vesicle
- Optic vesicles
- In human anatomy and morphology
- Seminal vesicle
- Vesicle (dermatology), a liquid-filled cavity under the epidermis, commonly called a blister
- In non-human morphology
- Subsporangial vesicle
- Juice vesicles, the pulp found in the endocarp of common citrus members
- In geology
- Vesicular texture, a small enclosed cavity found in some volcanic rock, such as basalt