VC may refer to:
- Vanadium carbide, an inorganic compound
- Vancouver Canucks, a NHL hockey team
- Vanier College
- Vassar College
- Vehicle code, a motor vehicle traffic legal system
- Venture capital (or venture capitalist), the financing of growing businesses
- Versus Christus, a reference to the Antichrist
- Vice chairman, the second chairman of a board or committee
- Vice-Chancellor, the chief executive of a university
- Victoria Cross, the highest British and Commonwealth award for valour in the face of the enemy
- Viet Cong, a military group allied with North Vietnam and opposed to South Vietnam and the United States during the Vietnam war
- Vigilance committee
- Vince Carter, a National Basketball Association player with the Phoenix Suns
- Vinyl chloride, a chemical used in the production of PVC
- Violoncello (usually abbreviated to cello), a bowed stringed instrument
- Virginia College
- Virtual Console, a Nintendo video game download service for the Wii, 3DS, and Wii U game consoles
- Visual Composer, a modeling tool
- Visual cryptography
- Vitamin C, an essential nutrient
- Voluntary controlled school
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