Vasculitis - Conditions

Conditions

Some disorders have vasculitis as their main feature. The major types are given in the table below:

Comparison of major types of vasculitis
Vasculitis Affected organs Histopathology
Cutaneous small-vessel vasculitis Skin, kidneys Neutrophils, fibrinoid necrosis
Wegener's granulomatosis Nose, lungs, kidneys Neutrophils, giant cells
Churg–Strauss syndrome Lungs, kidneys, heart, skin Histiocytes, eosinophils
Kawasaki disease Skin, heart, mouth, eyes Lymphocytes, endothelial necrosis
Buerger's disease Leg arteries and veins (gangrene) Neutrophils, granulomas

Takayasu's arteritis, polyarteritis nodosa and giant cell arteritis mainly involve arteries and are thus sometimes classed specifically under arteritis.

Furthermore, there are many conditions that have vasculitis as an accompanying or atypical symptom, including:

  • Rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and dermatomyositis
  • Cancer, such as lymphomas
  • Infections, such as hepatitis C
  • Exposure to chemicals and drugs, such as amphetamines, cocaine, and anthrax vaccines which contain the Anthrax Protective Antigen as the primary ingredient.

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