Biomedical Aspects
Vanadyl(acac) exhibits insulin mimetic properties, in that in can stimulate the phosphorylation of protein kinase B (PKB/Akt) and glycogen synthase kinase-3 (GSK3). It has also been shown inhibit tyrosine phosphatase(PTPase), PTPases such as PTP1B, which dephosphorylates insulin receptor beta subunit, thus increasing its phosphorylation, allowing for a prolonged activation of IRS-1, PKB, and GSK3, allowing them to exert their anti-diabetic properties.
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