Biomedical Aspects
Vanadyl(acac) exhibits insulin mimetic properties, in that in can stimulate the phosphorylation of protein kinase B (PKB/Akt) and glycogen synthase kinase-3 (GSK3). It has also been shown inhibit tyrosine phosphatase(PTPase), PTPases such as PTP1B, which dephosphorylates insulin receptor beta subunit, thus increasing its phosphorylation, allowing for a prolonged activation of IRS-1, PKB, and GSK3, allowing them to exert their anti-diabetic properties.
Read more about this topic: Vanadyl Acetylacetonate
Famous quotes containing the word aspects:
“That anger can be expressed through words and non-destructive activities; that promises are intended to be kept; that cleanliness and good eating habits are aspects of self-esteem; that compassion is an attribute to be prized—all these lessons are ones children can learn far more readily through the living example of their parents than they ever can through formal instruction.”
—Fred Rogers (20th century)