USS Spadefish has been the name of more than one United States Navy ship, and may refer to:
- USS Spadefish (SS-411), later AGSS-411, a submarine in commission from 1944 to 1946
- USS Spadefish (SSN-668), a submarine in commission from 1969 to 1997
| This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists. |