U.S. Route 45 in Illinois

In the U.S. state of Illinois, U.S. Route 45 is a major north–south highway that runs from the Irvin S. Cobb Bridge over the Ohio River at Brookport north through rural sections of eastern Illinois and then through the suburbs of Chicago to the Wisconsin border east of Antioch. This is a distance of 428.99 miles (690.39 km). U.S. 45 is the longest numbered route in Illinois.

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