Junction List
| County | Location | Mile | km | Exit | Destinations | Notes | |
|---|---|---|---|---|---|---|---|
| New Hanover |
Fort Fisher | 0.2 | 0.3 | Fort Fisher Ferry Terminal | US 421 begins .2 miles (0.32 km) south of terminal; ferry service to Southport | ||
| Myrtle Grove | 13.5 | 21.7 | NC 132 north (College Road) – Wilmington | Southern terminus of NC 132 | |||
| Wilmington | 15 | 24 | US 117 (Shipyard Boulevard) – Wilmington, State Port | ||||
| 18 | 29 | US 76 east / US 17 Bus. north (3rd Street) – Wrightsville Beach, Downtown Wilmington |
East end of US 76 overlap, north end of US 17 Business overlap | ||||
| 19 | 31 | Front Street | Partial interchange | ||||
| Brunswick |
21 | 34 | US 17 / NC 133 south / US 74 / US 76 west – Bolivia, Southport, Whiteville | South end of US 17/US 17 Business/NC 133 overlap, west end of US 74/76 overlap | |||
| New Hanover |
22 | 35 | U.S.S. North Carolina Road/Battleship Road | To the N.C. Battleship | |||
| 24 | 39 | US 74 east / NC 133 north – Wrightsville Beach, Hightsville | East end of US 74 overlap, north end of NC 133 overlap | ||||
| 25.5 | 41.0 | I-140 east / US 17 north – Hampstead, Topsail Island | North end of US 17 overlap | ||||
| Pender |
Long Creek | 38.5 | 62.0 | NC 210 – Rocky Point, Currie | Also to Moores Creek National Battlefield on west NC 210 | ||
| Malpass Corner | 44 | 71 | NC 11 south / NC 53 – Atkinson, Burgaw | South end of NC 11 overlap | |||
| 52 | 84 | NC 11 north – Penderlea, Willard | North end of NC 11 overlap | ||||
| Sampson |
Harrells | 60 | 97 | NC 41 (Tomahawk Highway/Wallace Highway) – Tomahawk, Wallace | |||
| Delway | 65 | 105 | NC 903 (Magnolia-Lisbon Road) – Magnolia, Kenansville | ||||
| Clinton | 79 | 127 | US 701 south (Garland Highway) / US 701 Bus. north (Sunset Boulevard) – Garland, Clinton |
South end of US 701 overlap | |||
| 80 | 129 | To NC 24 east (Tam Road) – Warsaw | |||||
| 81 | 130 | NC 24 east (Southwest Boulevard) – Warsaw | Southbound entrance and northbound exit, east end of NC 24 overlap | ||||
| 82 | 132 | NC 24 west (Sunset Avenue) – Roseboro, Fayetteville | West end of NC 24 overlap | ||||
| 83 | 134 | US 701 north (Faircloth Freeway) – Newton Grove | North end of US 701 overlap | ||||
| 95 | 153 | NC 242 south (Salemburg Highway) – Salemburg, Roseboro | South end of NC 242 overlap | ||||
| Spivey's Corner | 99 | 159 | US 13 (Fayetteville Highway/Newton Grove Highway) – Fayetteville, Newton Grove | ||||
| 100 | 161 | NC 242 north (Benson Highway) – Benson | North end of NC 242 overlap | ||||
| Harnett |
Dunn | 109 | 175 | I-95 / NC 55 east – Fayetteville, Benson, Newton Grove | East end of NC 55 overlap | ||
| 110 | 177 | US 301 (Clinton Avenue) – Fayetteville, Benson | |||||
| Erwin | 114 | 183 | NC 55 north / NC 82 south / NC 217 south (13th Street) – Erwin, Coats | West end of NC 55 overlap | |||
| 119 | 192 | NC 27 east – Coats | East end of NC 27 overlap; Harnett County Airport at intersection | ||||
| Lillington | 124 | 200 | US 401 north (Cornelius Harnett Boulevard) / NC 210 north (Main Street) – Fuquay-Varina | North end of US 401 and NC 210 overlap | |||
| 125 | 201 | US 401 south / NC 27 east / NC 210 south (Main Street) | South end of US 401/NC 210 overlap, east end of NC 27 overlap | ||||
| Lee |
Sanford | 144 | 232 | NC 87 south – Fayetteville | South end of NC 87 overlap (Future Exit 143 on Sanford Bypass) | ||
| 145 | 233 | NC 42 east / NC 78 west (Main Street) – Fuquay-Varina | East end of NC 42 overlap (Future Exit 144 on Sanford Bypass) | ||||
| 147 | 237 | US 1 Bus. / NC 42 west (Carthage Street) |
West end of NC 42 overlap; also junction of U.S. Bike Route 1 | ||||
| 149 | 240 | US 1 / US 15 / US 501 / NC 87 north – Raleigh, Southern Pines | North end of NC 87 overlap (Future Exit 149 on Sanford Bypass) | ||||
| Chatham |
163 | 262 | NC 902 – Pittsboro | ||||
| 168 | 270 | 168 | Sam Fields Road – Siler City | ||||
| Siler City | 171 | 275 | 171 | US 64 – Siler City, Pittsboro | |||
| 174 | 280 | 174 | Piney Grove Church Road | ||||
| Randolph |
Staley | 180 | 290 | 180 | Old US Highway 421 – Liberty, Staley | ||
| Liberty | 181 | 291 | 181 | NC 49 – Liberty, Ramseur | |||
| 184 | 296 | Old Liberty Road – Liberty | |||||
| Guilford |
Julian | 190 | 306 | NC 62 – High Point, Burlington | |||
| 197 | 317 | 197 | I-85 north to I-40 – Durham, Raleigh | North end of I-85 overlap | |||
| US 421 overlaps with Interstate 85 (exits 126 to 121), Interstate 73 (exits 97 to 103), Interstate 40 (exits 212 to 206), and Interstate 40 Business (exits 16 to 1). | |||||||
| Forsyth |
Winston-Salem | 234 | 377 | 238 | I-40 / I-40 Bus. east – Winston-Salem, Statesville | West end of Interstate 40 Business overlap | |
| 235 | 378 | 239 | Jonestown Road | ||||
| 236 | 380 | 240 | Peace Haven Road | ||||
| Lewisville | 238 | 383 | 242 | Lewisville-Clemmons Road – Lewisville, Clemmons | |||
| 240 | 386 | 244 | Williams Road – Lewisville | ||||
| 242 | 389 | 246 | Shallowford Road | ||||
| Yadkin |
245 | 394 | 249 | Dinkins Bottoms Road/Baltimore Road | |||
| 247 | 398 | 251 | Spear Bridge Road | ||||
| 249 | 401 | 253 | Shacktown Road/Old Stage Road | ||||
| 252 | 406 | 256 | Unifi Industrial Road | ||||
| Yadkinville | 253 | 407 | 257 | US 601 (State Street) – Yadkinville, Mocksville | |||
| 255 | 410 | 259 | Reavis Road | ||||
| Brooks Crossroads | 259 | 417 | 263 | US 21 – Jonesville | |||
| 260 | 418 | 264 | Asbury Church Road | ||||
| 262 | 422 | 265 | I-77 – Elkin, Statesville, Charlotte | Northbound is exit 265A, southbound is exit 265B | |||
| 264 | 425 | 267 | Windsor Road/Oak Grove Church Road | ||||
| Wilkes |
267 | 430 | 270 | Dennyville Road | |||
| 269 | 433 | 272 | To NC 268 (Clingman Road/Somers Road) | ||||
| 273 | 439 | 276 | To NC 268 (Red, White, and Blue Road/Mathis Farm Road) | ||||
| 274 | 441 | 277 | Windy Gap Road/Speedway Road | ||||
| 279 | 449 | 282 | US 421 Bus. / NC 115 (Statesville Road) – North Wilkesboro, Statesville |
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| Wilkesboro | 282 | 454 | 285 | Brushy Mountain Road – Wilkesboro | |||
| 283 | 455 | 286A | NC 16 south / NC 18 (Cherry Road) – Wilkesboro, Taylorsville, Lenoir | South end of NC 16 overlap | |||
| 283.5 | 456.2 | NC 268 – Wilkesboro | |||||
| 284 | 457 | US 421 Bus. (D Street) – North Wilkesboro |
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| 287 | 462 | NC 16 north – Jefferson | North end of NC 16 overlap | ||||
| Watauga |
Deep Gap | 304 | 489 | Blue Ridge Parkway | |||
| 305 | 491 | US 221 north – West Jefferson | North end of US 221 overlap | ||||
| Boone | 313 | 504 | NC 194 north (Jefferson Road) – Todd | North end of NC 194 overlap | |||
| 314 | 505 | US 221 south / NC 105 south (Highway 105 Extension) – Linville, Banner Elk | South end of US 221 overlap | ||||
| 314.5 | 506.1 | US 321 south (Hardin Street) – Blowing Rock | South end of US 321 overlap | ||||
| Vilas | 320 | 515 | NC 194 south – Valle Crucis | South end of NC 194 overlap | |||
| Sugar Grove | 321 | 517 | US 321 north – Elizabethton | North end of US 321 overlap | |||
| State line | 328 | 528 | US-421 north / SR-34 north – Mountain City | ||||
|
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Note – Exit numbers west of Winston-Salem are aligned when US 421 went north around Greensboro in late-1980s/early-1990s. As a result from realignments in Greensboro, the actual mileage vs. exit number mileage is off by an average of 3.5 miles (5.6 km).
Read more about this topic: U.S. Route 421 In North Carolina
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