U.S. Route 395

U.S. Route 395 is a U.S. Route in the western United States. The southern terminus of the route is in the Mojave Desert at Interstate 15 near Hesperia. The northern terminus is at the Canadian border near Laurier, where the road becomes Highway 395 upon entering British Columbia. At one time, the route extended south to San Diego. I-15 replaced the stretch of 395 that ran from San Diego to Hesperia. Old 395 can be seen along I-15 in many locations before it branches off at Hesperia to head North.

The route runs through the U.S. states of California, Nevada, Oregon, and Washington. US 395 runs along the east side of the Sierra Nevada in the Owens Valley and crosses through the Modoc Plateau along its routing.

The route started out as a spur of U.S. Route 195 and ran north from Spokane. As a result, the route never intersects its parent, U.S. Route 95; it maintains a connection through US 195. US 395 developed into a parallel of its parent route when extended south in the early 1930s. US 395 stays west of its parent route, which runs through Arizona, Nevada, and Idaho.