U.S. Route 221 is a spur of U.S. Route 21. It runs for 734 miles (1,181 km) from Perry, Florida at US Routes 19/98/ALT 27 to Lynchburg, Virginia at U.S. Route 29 (Lynchburg Expressway). It passes through the states of Florida, Georgia, South Carolina, North Carolina, and Virginia. It goes through the cities of Valdosta, Georgia, Spartanburg, South Carolina, Roanoke, Virginia, and Lynchburg, Virginia.
Throughout western North Carolina from the Virginia border to the Blue Ridge Parkway, U.S. 221 is a challenging drive, and can be described as one climb after another. There are few places where the road builders attempted to skirt around large foothills.
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