Junction List
| County | Location | Mile | km | Exit | Destinations | Notes |
|---|---|---|---|---|---|---|
| Beaufort |
0.0 | 0.0 | Hunting Island State Park | US 21 begins at intersection of walking trail, road continues south to Fripp Island | ||
| Beaufort | 14.5 | 23.3 | US 21 Bus. north / SC 802 east |
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| 17 | 27 | SC 281 north (Ribaut Road) | ||||
| 20.8 | 33.5 | SC 128 west (Savannah Highway) – Bluffton, Hardeeville, Hilton Head Island | ||||
| 23.9 | 38.5 | SC 170 west – Beaufort | ||||
| 25.2 | 40.6 | US 21 Bus. south – Beaufort |
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| 27 | 43 | SC 116 west – Laurel Bay | ||||
| Gardens Corner | 34.5 | 55.5 | US 17 north (Charleston Highway) – Charleston | North end of US 17 overlap | ||
| Pocotaligo | 41 | 66 | US 17 south / US 17 Alt. north – Ridgeland, Yemassee |
South end of US 17 and US 17 Alt. overlap | ||
| Hampton |
Yemassee | 45 | 72 | SC 68 west (Yemassee Highway) – Varnville, Hampton | ||
| Colleton |
48.5 | 78.1 | US 17 Alt. north (Hendersonville Highway) – Walterboro |
North end of US 17 Alt. overlap | ||
| 51 | 82 | I-95 – Florence, Savannah | ||||
| 61 | 98 | SC 63 (Sniders Highway) – Varnville, Walterboro | ||||
| 67.5 | 108.6 | SC 64 (Bells Highway) – Ehrhardt, Walterboro | ||||
| Smoaks | 76 | 122 | SC 217 (Lodge Highway) – Lodge | |||
| Bamberg |
82 | 132 | SC 61 (Edisto River Road) – Bamberg | |||
| Orangeburg |
Branchville | 88.0– 88.2 |
141.6– 141.9 |
US 78 – Bamberg, Charleston | 0.2-mile (0.32 km) concurrency | |
| 88.5 | 142.4 | SC 210 north – Bowman | ||||
| Orangeburg | 103.8 | 167.0 | US 21 Bus. north (Rowesville Road) |
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| 104 | 167 | US 178 east (Charleston Highway) / US 178 Bus. – Summerville, Charleston |
East end of US 178 overlap | |||
| 105 | 169 | US 301 (Five Chop Road) – Santee | ||||
| 106 | 171 | SC 33 (Russel Street) – Cameron | ||||
| 107 | 172 | US 601 (Magnolia Street) – St. Matthews | ||||
| 108 | 174 | US 178 (Chestnut Street) / US 21 Bus. (Columbia Road) – North |
West end of US 178 overlap | |||
| Calhoun |
120 | 193 | SC 6 south (Cawcaw Road) / SC 172 west (Bull Swamp Road) – St. Matthews, North | South end of SC 6 overlap | ||
| 122 | 196 | SC 6 north (Center Hill Road) – Swansea | North end of SC 6 overlap | |||
| Lexington |
127 | 204 | I-26 – Columbia, Charleston | |||
| Calhoun |
130 | 209 | US 176 east (Old State Road) – St. Matthews | East end of US 176 overlap | ||
| Lexington |
137 | 220 | I-26 – Columbia, Charleston | |||
| 138 | 222 | US 321 south – Gaston, Swansea | South end of US 321 overlap | |||
| Cayce | 141 | 227 | To I-77 (Fish Hatchery Road) – Charlotte | |||
| 141.5 | 227.7 | I-26 – Charleston, Spartanburg | ||||
| 142.5 | 229.3 | SC 2 north (Frink Road) | ||||
| West Columbia | 144 | 232 | SC 302 south (Airport Boulevard) – Aiken, Columbia Metropolitan Airport | |||
| 146 | 235 | SC 2 (State Street) | ||||
| Richland |
Columbia | 147 | 237 | US 1 / US 378 (Gervais Street) | To South Carolina State House | |
| 147.5 | 237.4 | SC 12 (Hampton/Tylor Streets) | To Finlay Park and Columbia Museum of Art | |||
| 148 | 238 | I-126 west / US 76 west – Greenville, Spartanburg | West end of US 76 overlap | |||
| 148.5 | 239.0 | US 76 east (Elmwood Avenue) | East end of US 76 overlap | |||
| 149 | 240 | US 176 west (River Drive) | West end of US 176 overlap | |||
| 150 | 241 | SC 16 (Sunset Drive) | ||||
| 151 | 243 | SC 215 north (Montichello Road) | To Columbia International University | |||
| 152 | 245 | US 321 north (Fairfield Street) | ||||
| 154 | 248 | I-20 – Florence, Augusta | ||||
| 161 | 259 | I-77 – Columbia, Charlotte | ||||
| 161 | 259 | SC 555 (Farrow Road) – Columbia | ||||
| Fairfield |
Ridgeway | 171.0– 171.2 |
275.2– 275.5 |
SC 34 – Lugoff, Camden, Winnsboro Mills | 0.2-mile (0.32 km) concurrency | |
| 188 | 303 | SC 200 – Winnsboro | South end of SC 200 overlap | |||
| Chester |
Great Falls | 191 | 307 | SC 99 north (Chester Avenue) – Richburg | ||
| 192 | 309 | SC 97 / SC 200 north – Chester, Lancaster | North end of SC 200 overlap, brief 0.1-mile (0.16 km) concurrency with SC 97 | |||
| Fort Lawn | 200 | 322 | SC 9 (Chester Avenue) – Richburg, Lancaster | |||
| 205 | 330 | SC 223 (Wylies Mill Road) – Richburg | ||||
| York |
Lesslie | 212 | 341 | SC 5 south – Lexington | ||
| Rock Hill | 216 | 348 | Springfield Road – Lesslie | Exit ramps not clearly marked | ||
| 217 | 349 | I-77 – Columbia, Charlotte | ||||
| 217.5 | 350.0 | US 21 Bus. north / SC 5 north (Main Street) |
North end of SC 5 overlap | |||
| 218 | 351 | SC 121 south (Cowan Road) | South end of SC 121 overlap | |||
| 219 | 352 | SC 122 (Dave Lyle Boulevard) | ||||
US 21 Bus. south (Cherry Road) / SC 121 |
North end of SC 121 overlap | |||||
| 222 | 357 | I-77 / SC 161 west (Celanese Road) – Columbia, Charlotte | ||||
| Fort Mill | 223.5 | 359.7 | US 21 Bus. north (Spratt Street) |
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| 225 | 362 | SC 160 | ||||
| 228 | 367 | SC 460 (Springfield Parkway) – Tega Cay, Fort Mill | ||||
| 229 | 369 | US 21 Bus. south (Old Nation Road) |
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| 230 | 370 | SC 51 north (Pineville-Rock Hill Road) – Pineville | ||||
| 230.5 | 371.0 | I-77 south / Carowinds Boulevard – Columbia | South end of I-77 overlap; to Carowinds | |||
| |
South Carolina–North Carolina state line | |||||
| Mecklenburg |
Charlotte | 1A | Westinghouse Boulevard | Formerly exit 1 before August 2010 | ||
| 1B | I-485 – Huntersville, Pineville | Formerly exit 2 (southbound) before August 2010 | ||||
| 3 | Arrowood Road | Formerly exit 2 (northbound) before August 2010 | ||||
| 4 | Nations Ford Road | |||||
| 5 | Tyvola Road | |||||
| 6A | Woodlawn Road south – Queens University | To Pfeiffer University | ||||
| 6B | NC 49 (South Tryon Street) / Billy Graham Parkway | To Billy Graham Library | ||||
| 7 | To NC 49 / Clanton Road | |||||
| 8 | To NC 160 / Remount Road | Northbound exit and southbound entrance | ||||
| 9A | NC 160 (West Boulevard) | Southbound exit and northbound entrance | ||||
| 9B | I-277 north (John Belk Freeway) / US 74 east | |||||
| 9C | US 74 west (Wilkinson Boulevard) | |||||
| 10A | US 29 / NC 27 (Morehead Street) | Northbound exit is via exit 9C | ||||
| 10 | Trade Street, Fifth Street | Signed as exits 10B (Trade Street east) and 10C (Trade Street west, Fifth Street) southbound | ||||
| 11A | I-277 south / NC 16 south (Brookshire Freeway east) – Downtown Charlotte | |||||
| 11B | NC 16 north (Brookshire Freeway west) | Northbound left exit | ||||
| 12 | Lasalle Street | |||||
| 13 | I-85 – Greensboro, Spartanburg | Signed as exits 13A (north) and 13B (south) | ||||
| 16 | 26 | 16 | I-77 north – Statesville | North end of I-77 overlap | ||
| 16.5 | 26.6 | NC 155 north (Old Statesville Road) | ||||
| 19 | 31 | NC 24 (W.T. Harris Boulevard) | ||||
| Huntersville | 25.5 | 41.0 | NC 73 (Sam Fur Road) – Concord | |||
| Cornelius | 25.5 | 41.0 | 28 | I-77 south – Charlotte | South end of I-77 overlap | |
| Davidson | 30 | Davidson, Davidson College | ||||
| Iredell |
Mooresville | 31 | Langtree Road | |||
| 33.5 | 53.9 | 33 | I-77 north – Statesville | North end of I-77 overlap | ||
| 36.5 | 58.7 | NC 150 (Plaza Drive) | ||||
| 36.5 | 58.7 | NC 155 south (Statesville Highway) | South end of NC 155 overlap | |||
| 43 | 69 | I-77 – Charlotte, Statesville | ||||
| Statesville | 51 | 82 | US 70 (Garner Bagnal Boulevard) – Conover, Salisbury | |||
| 52 | 84 | US 64 west (Front Street) / NC 90 west (Water Street) / NC 115 north (Center Street) | US 21 zig-zags through downtown Statesville; west end of US 64 overlap, north end of NC 115 overlap | |||
| 53 | 85 | US 64 east (Davie Avenue) – Mocksville | East end of US 64 overlap | |||
| 54 | 87 | I-40 – Hickory, Winston-Salem | ||||
| 57.5 | 92.5 | I-77 – Statesville, Elkin | ||||
| Harmony | 67 | 108 | NC 901 (Memorial Highway) – Union Grove | |||
| Yadkin |
Brooks Crossroads | 79 | 127 | US 421 – Wilkesboro, Yadkinville, Winston-Salem | ||
| 85.5 | 137.6 | 79 | I-77 south / US 21 Bus. north – Statesville, Jonesville |
South end of I-77 overlap | ||
| Jonesville | 82 | NC 67 – Jonesville, Boonville, Elkin | ||||
| Surry |
Elkin | 90 | 145 | 83 | I-77 north – Wytheville | North end of I-77 overlap; southbound exit and northbound entrance |
| 91.5 | 147.3 | NC 268 – Elkin | To Elkin Municipal Airport | |||
| 93 | 150 | US 21 Bus. south / Popular Springs Road – Elkin |
Northbound turn left on Popular Springs Road to US 21 Business | |||
| Alleghany |
111 | 179 | Blue Ridge Parkway | |||
| Sparta | 118.5 | 190.7 | NC 18 (Whitehead Street) – Laurel Springs | |||
| Twin Oaks | 121 | 195 | US 221 south – Jefferson | South end of US 221 overlap | ||
| |
North Carolina–Virginia state line | |||||
| Grayson |
Independence | 4 | 6 | US 58 / US 221 north (Main Street) – Mouth of Wilson, Galax | North end of US 221 overlap | |
| Elk Creek | 13 | 21 | Corners Rock Road | |||
| Wythe |
Speedwell | 21 | 34 | SR 619 east / SR 749 west | ||
| Wytheville | 33.5 | 53.9 | US 11 (Lee Highway/Main Street) | 0.4-mile (0.64 km) concurrency | ||
| 35 | 56 | I-81 / US 52 – Bristol, Roanoke | ||||
1.000 mi = 1.609 km; 1.000 km = 0.621 mi
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Read more about this topic: U.S. Route 21
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