Major Intersections
| County | Location | Mile | km | Destinations | Notes |
|---|---|---|---|---|---|
| Greene |
Perry Township | 0.0 | 0.0 | US 19 | US 19 enters Pennsylvania from West Virginia. |
| Morrisville | 15.4 | 24.8 | PA 21 (Montgomery Street) | Southern terminus of concurrency | |
| Waynesburg | 16.8 | 27.0 | PA 21 west (High Street) | Northern terminus of concurrency | |
| Washington Township | 21.9 | 35.2 | PA 221 | PA 221 provides access to I-79 North; I-79 exit 19 | |
| 22.1 | 35.6 | I-79 south | I-79 exit 19 | ||
| Washington |
South Strabane Township | 33.6 | 54.1 | I-79 | I-79 exit 30 |
| 37.0 | 59.5 | US 40 east (Maiden Street) | Southern terminus of concurrency with US 40 | ||
| Washington | 39.0 | 62.8 | US 40 west (Maiden Street) | Northern terminus of concurrency with US 40 | |
| 39.2 | 63.1 | PA 136 (Beau Street) | |||
| South Strabane Township | 40.6 | 65.3 | I-70 / I-79 | I-70 exit 19 | |
| North Strabane Township | 45.5 | 73.2 | PA 519 | ||
| 46.4 | 74.7 | PA 980 | Southern terminus of PA 980 | ||
| Allegheny |
Mt. Lebanon | 58.1 | 93.5 | US 19 Truck (Washington Road) |
Southern terminus of US Truck 19 |
| 59.1 | 95.1 | PA 121 (Cochran Road) | Southern terminus of PA 121 | ||
| Pittsburgh | 62.8 | 101.1 | I-376 / US 22 / US 30 (Penn-Lincoln Parkway) / PA 51 south (Saw Mill Run Boulevard) | Southern terminus of concurrency with PA 51. | |
| 64.1 | 103.2 | PA 51 north / PA 60 / PA 837 (Carson Street) | Northern terminus of concurrency with PA 51; Northern terminus of PA 837, Southern terminus of PA 60; West End Circle |
||
| Ohio River | West End Bridge | ||||
| Pittsburgh | 64.6 | 104.0 | PA 65 south | Southern terminus of concurrency | |
| 65.3 | 105.1 | PA 65 north | Northern terminus of concurrency | ||
| 69.4 | 111.7 | I-279 | Interchange, I-279 exit 12 via Cemetery Lane | ||
| 69.9 | 112.5 | I-279 south | HOV Only | ||
| McCandless Township | 76.2 | 122.6 | US 19 Truck (McKnight Road) |
Northern terminus of US Truck 19, Southbound access only | |
| Wexford | 78.9 | 127.0 | PA 910 (Wexford Road) | ||
| Marshall Township | 82.2 | 132.3 | I-79 south | Southbound access only; I-79 exit 75 | |
| Butler |
Cranberry Township | 83.3 | 134.1 | I-76 / Penna. Tpk. | |
| 83.8 | 134.9 | PA 228 | Western terminus of PA 228 | ||
| Jackson Township | 88.8 | 142.9 | PA 528 (Lindsay Road) | Southern terminus of PA 528; I-79 exit 85 | |
| Zelienople | 90.2 | 145.2 | I-79 | ||
| 91.6 | 147.4 | PA 68 west (Beaver Street) | Eastern terminus of concurrency | ||
| 91.9 | 147.9 | PA 288 (New Castle Street) | Eastern terminus of PA 288 | ||
| 92.0 | 148.1 | PA 68 east (Grandview Avenue) | Western terminus of concurrency | ||
| Portersville | 101.4 | 163.2 | PA 488 east (Portersville Road) | Eastern terminus of concurrency | |
| 101.6 | 163.5 | PA 488 west (Portersville Road) | Western terminus of concurrency | ||
| Muddy Creek Township | 104.7 | 168.5 | US 422 (New Castle Road) | ||
| Lawrence |
Harlansburg | 105.8 | 170.3 | PA 108 | |
| 106.1 | 170.8 | PA 956 | Southern terminus of PA 956 | ||
| Mercer |
Leesburg | 112.5 | 181.1 | PA 208 west (Leesburg Volant Road) | Southern terminus of concurrency |
| 112.6 | 181.2 | PA 208 east (Leesburg Grove City Road) | Northern terminus of concurrency | ||
| Findley Township | 116.9 | 188.1 | I-80 | I-80 exit 15 | |
| Mercer | 119.1 | 191.7 | PA 318 (Butler Street) | ||
| 119.2 | 191.8 | US 62 south / PA 258 (Market Street) | Southern termini of concurrency with US 62 and PA 258 | ||
| 119.22 | 191.87 | PA 58 east / PA 258 south (Diamond Street) | Southern terminus of concurrency with PA 58, northern terminus of concurrency with PA 258. |
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| 119.4 | 192.2 | PA 58 west (Greenville Avenue) | Northern terminus of concurrency with PA 58 | ||
| 119.8 | 192.8 | US 62 north (Franklin Road) | Northern terminus of concurrency with US 62 | ||
| Perry Township | 131.2 | 211.1 | PA 358 (Hadley Road) | ||
| Crawford |
Greenwood Township | 141.4 | 227.6 | PA 285 | |
| Meadville | 147.2 | 236.9 | US 6 west / US 322 west (Conneaut Lake Road) / PA 98 | Southern terminus of concurrency with US 6/US 322; southern terminus of PA 98. |
|
| 148.4 | 238.8 | I-79 | I-79 exit 147 | ||
| 149.0 | 239.8 | PA 102 (Pennsylvania Avenue) | Southern terminus of PA 102 | ||
| 150.1 | 241.6 | US 322 east (Linden Street) | Northern terminus of concurrency with US 322 Also provides access to PA 27 |
||
| Saegertown | 156.5 | 251.9 | PA 198 east (State Street) | Southern terminus of concurrency | |
| 157.2 | 253.0 | PA 198 west | Northern terminus of concurrency | ||
| Cambridge Springs | 165.2 | 265.9 | PA 86 south (Main Street) / PA 408 (Church Street) | Northern terminus of PA 86 Western terminus of PA 408 |
|
| 165.4 | 266.2 | PA 99 (McClellan Street) | Southern terminus of PA 99 and northern terminus of concurrency with PA 86 | ||
| Erie |
Mill Village | 171.4 | 275.8 | US 6 east / US 6N | Eastern terminus of US 6N Northern terminus of concurrency with US 6 |
| Waterford | 175.2 | 282.0 | PA 97 south | Southern terminus of concurrency | |
| 176.7 | 284.4 | PA 97 north (Perry Highway) | Northern terminus of concurrency | ||
| Summit Township | 184.8 | 297.4 | I-90 | I-90 exit 24 | |
| Millcreek Township | 186.1 | 299.5 | PA 99 (Interchange Road) | Northern terminus of PA 99 | |
| Erie | 189.5 | 305.0 | US 20 (26th Street) | Northern terminus of US 19 | |
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