Antiuricosurics
Antiuricosuric drugs raise serum uric acid levels and lower urine uric acid levels. These drugs include all diuretics, pyrazinoate, pyrazinamide, ethambutol, and aspirin. The NSAID diclofenac has an antiuricosuric action, which may be partly responsible for the extraordinary toxicity of this drug in vultures.
Pyrazinamide, a drug indicated only for treatment of tuberculosis, is a potent antiuricosuric and, as a consequence, has an off-label use in the diagnosis of causes of abnormal uric acid clearance. It acts on URAT1.
Antiuricosuric drugs are useful for treatment of hypouricemia and perhaps also hyperuricosuria, but are contraindicated in persons with conditions including hyperuricemia and gout.
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