Upham is a surname, and may refer to
- Alexander Upham (1802–1841), farmer, merchant, ship builder and political figure in Nova Scotia, Canada
- Alonzo S. Upham (1811–1882), New York politician
- Bill Upham (1888–1959), U.S. major league baseball pitcher
- Charles Upham VC and Bar (1908–1994), New Zealand soldier, most decorated Commonwealth soldier in WW2
- Charles W. Upham (1802–1875), historian and U.S. Representative from Massachusetts
- Chet Upham (1925–2008), oil and natural gas businessman, chairman of the Texas Republican Party 1979-1983
- Daniel Phillips Upham (1832–1882), Republican politician and Arkansas State Militia commander
- Don A. J. Upham (1809–1877), American lawyer and Wisconsin politician
- Ernest Upham (1873–1935), New Zealand cricketer
- Frank B. Upham (1872–1939), U.S. Navy admiral
- George B. Upham (1768–1848), U.S. Representative from New Hampshire
- Jabez Upham (1764–1811), U.S. Representative from Massachusetts
- Joshua Upham (1741–1808), American lawyer who became a judge and political figure in New Brunswick, Canada
- Misty Upham (born 1982), Native American actress
- Nathaniel Upham (1774–1829), U.S. Representative from New Hampshire
- Oscar J. Upham (1871–1949), U.S. Marine, Medal of Honor recipient
- Richard Upham (1716–1775?), political figure in Nova Scotia, Canada
- Samuel C. Upham (1819–1885), American journalist and counterfeiter of Confederate money
- Steadman Upham, American anthropologist, University of Tulsa president
- Thomas Cogswell Upham (1799–1872), American philosopher and educator
- Timothy Upham (1783–1855), American soldier in the war of 1812, subsequently Collector of Customs and politician
- Warren Upham (1850–1934), American geologist, archaeologist and librarian
- William Upham (1792–1853), U.S. Senator from Vermont
- William H. Upham (1841–1924), U.S. Army major, businessman and governor of Wisconsin