Chemical Inducers
UPR inducers most notably include tunicamycin. Others are:
- thapsigargin Leads to ER Ca+2 depletion due to inhibition of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA).
- A23187
- 2-deoxyglucose
- dithiothreitol Reduce the disulfide bridges of proteins. The denatured proteins accumulated inside the ER.
- fenretinide and bortezomib (Velcade), each acting via different cellular mechanisms, induce ER stress leading to apoptosis in melanoma cells.
Read more about this topic: Unfolded Protein Response
Famous quotes containing the word chemical:
“Ants are so much like human beings as to be an embarrassment. They farm fungi, raise aphids as livestock, launch armies into war, use chemical sprays to alarm and confuse enemies, capture slaves, engage in child labor, exchange information ceaselessly. They do everything but watch television.”
—Lewis Thomas (b. 1913)