UDP-glucuronate Decarboxylase

In enzymology, an UDP-glucuronate decarboxylase (EC 4.1.1.35) is an enzyme that catalyzes the chemical reaction

UDP-D-glucuronate UDP-D-xylose + CO₂

Hence, this enzyme has one substrate, UDP-D-glucuronate, and two products, UDP-D-xylose and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming). Other names in common use include uridine-diphosphoglucuronate decarboxylase, and UDP-D-glucuronate carboxy-lyase. This enzyme participates in starch and sucrose metabolism and nucleotide sugars metabolism. It employs one cofactor, NAD+.