Structure
The U4 snRNA secondary structure is suggested to alter depending on its interaction with the U6 snRNA. Several experiments involving X-ray crystallography, NMR, and chemical modification RNA structure probing indicate that U4 snRNA secondary structure contains several conserved motifs, which serve structural as well as intermediary roles in establishing interactions with other splicing components. The putative U4/U6 snRNA base pairing secondary structure shown in Figure 2., is conserved across a diverse set of organisms suggesting the splicing machinery's ancient origins. It has been shown previously that a highly conserved Kinked-loop participates in specific protein interactions.
Read more about this topic: U4 Spliceosomal RNA
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