Tyree may refer to:
- David Tyree (born 1980), American football player
- Elizabeth Tyree (1865–1952), American stage actress
- Omar Tyree (born 1969), American novelist
- Ralph Burke Tyree (1921-1979), American painter
- Clinton Tyree, a character in the work of Carl Hiaasen
- Tyree (Star Trek planet)
- Tyree (musician), hip house artist
- Bill Tyree, actor, featured in Homo Erectus
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