Inhibition
As topoisomerases generate breaks in DNA, they are targets of small-molecule inhibitors that inhibit the enzyme. Type 1 topoisomerase is inhibited by irinotecan, topotecan and camptothecin.
Read more about this topic: Type I Topoisomerase
Inhibition
As topoisomerases generate breaks in DNA, they are targets of small-molecule inhibitors that inhibit the enzyme. Type 1 topoisomerase is inhibited by irinotecan, topotecan and camptothecin.
Read more about this topic: Type I Topoisomerase