Troponin T is a part of the troponin complex. It binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex.
The tissue specific subtypes are:
- Slow skeletal troponin T1, TNNT1 (19q13.4, 191041)
- Cardiac troponin T2, TNNT2 (1q32, 191045)
- Fast skeletal troponin T3, TNNT3 (11p15.5, 600692)
Troponin T binds to tropomyosin and helps position it on actin. And in a less complicated light, Troponin T modulates contraction of striated muscle
Troponin T was discovered by the German physician Hugo A. Katus at the University of Heidelberg. He developed the troponin T assay.
In patients with stable coronary artery disease, troponin T concentrations have been found to be significantly associated with the incidence of cardiovascular death and heart failure, but not with myocardial infarction.