Implications of Trogocytosis in Serotherapeutic Approaches
Therapeutic antibodies can be used to treat cancer. An example is rituximab, a therapeutic antibody used to treat chronic lymphocytic leukemia recognizes the CD20 molecule expressed by tumor cells and leads to their elimination. However, using too much of the antibody results in part from the removal of rituximab-CD20 complexes from the tumor cell surface by monocytes through trogocytosis. This effect leads to tumors cell escape by antigenic modulation. Reducing the dose of therapeutic antibodies to limit the extent of trogocytosis might improve their therapeutic efficay.
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