Origin of The Name trk
The abbreviation trk (often pronounced 'track') stands for tropomyosin-receptor-kinase (and not tyrosine kinase nor tropomyosin-related kinase, as has been commonly mistaken).
The family of Trk receptors is named for the oncogene trk, whose identifical led to the discovery of its first member, TrkA. trk, initially identified in a colon carcinoma, is frequently (25%) activated in thyroid papillary carcinomas. The oncogene was generated by a mutation in chromosome 1 that resulted in the fusion of the first seven exons of tropomyosin to the transmembrane and cytoplasmic domains of the then-unknown TrkA receptor. Normal Trk receptors do not contain amino acid or DNA sequences related to tropomyosin.
Read more about this topic: Trk Receptor
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