Treatment
Standard treatment is surgery with adjuvant chemotherapy and radiotherapy. As a variation neoadjuvant chemotherapy is very frequently used for triple negative breast cancers. This allows for a higher rate of breast-conserving surgeries and by evaluating the response to the chemotherapy gives important clues about the individual responsiveness of the particular cancer to chemotherapy.
Triple negative breast cancers are generally very susceptible to chemotherapy; however, in some cases early complete response does not correlate with overall survival. This makes it particularly complicated to find the optimal chemotherapy. Adding a taxane to the chemotherapy appears to improve outcome substantially.
BRCA1-related triple negative breast cancer appear to be particularly susceptible to chemotherapy including platinum-based agents and taxanes.
Read more about this topic: Triple-negative Breast Cancer
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