Structure
The tripartite motif is always present at the N-terminus of the TRIM proteins. The TRIM motif includes the following three domains:
- (1) a RING finger domain
- (2) one or two B-box zinc finger domains
- when only one B-box is present, it is always a type-2 B-box
- when two B-boxes are present the type-1 B-Box always precedes the type-2 B-Box
- (3) coiled coil region
The C-terminus of TRIM proteins contain either:
- Group 1 proteins: a C-terminal domain selected from the following list:
- NHL and IGFLMN domains, either in association or alone
- PHD domain associated with a bromodomain
- MATH domain (in e.g., TRIM37)
- ARF domain (in e.g., TRIM23)
- EXOIII domain (in e.g., TRIM19) or
- Group 2 proteins: a SPRY C-terminal domain
- e.g. TRIM21
Read more about this topic: Tripartite Motif Family
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