TRD may refer to:
- Toyota Racing Development, the in-house tuning shop for Toyota-brand automobiles
- Treatment-resistant depression (or Treatment Refractory Depression), a type of depression used to describe individuals diagnosed with major depressive disorder and do not respond to traditional forms of treatment (namely, medication and psychotherapy)
- Tucson Roller Derby, the roller derby league located in Tucson, Arizona
- Trondheim Airport, Værnes (IATA Airport Code TRD)
- Thai Ridgeback Dog