Members of The Complex
The translocase of the outer membrane (TOM) forms a complex made of Tom70, Tom22, and Tom20, along with Tom40, Tom7, Tom6, and Tom5. Tom20 and Tom22 are preprotein receptors, which are responsible for recognition of the cleavable presequence possessed by mitochondrial-targeted proteins. Tom70 is also a preprotein receptor and may recognise some cleavable presequence proteins, however it is mainly responsible for the recognition of non-cleavable preproteins and acts as a point for chaperone binding. Tom22 is anchored to the outer membrane by a single transmembrane segment and also plays a role in stabilizing the TOM complex. Tom40 is the core element of the translocase complex and complexes with Tom22 with a mass of approximately 350k Daltons. It forms the central protein-conducting channel with a diameter of approximately 2.5 nm. The human Tom22 is approximately 15.5k Daltons and complexes with Tom20. The N-terminal end of Tom22 extends into the cytosol and is involved in preprotein binding.
Read more about this topic: Translocase Of The Outer Membrane
Famous quotes containing the words members of the, members of, members and/or complex:
“It took six weeks of debate in the Senate to get the Arms Embargo Law repealed—and we face other delays during the present session because most of the Members of the Congress are thinking in terms of next Autumn’s election. However, that is one of the prices that we who live in democracies have to pay. It is, however, worth paying, if all of us can avoid the type of government under which the unfortunate population of Germany and Russia must exist.”
—Franklin D. Roosevelt (1882–1945)
“I rejoice that horses and steers have to be broken before they can be made the slaves of men, and that men themselves have some wild oats still left to sow before they become submissive members of society. Undoubtedly, all men are not equally fit subjects for civilization; and because the majority, like dogs and sheep, are tame by inherited disposition, this is no reason why the others should have their natures broken that they may be reduced to the same level.”
—Henry David Thoreau (1817–1862)
“Two myths must be shattered: that of the evil stepparent . . . and the myth of instant love, which places unrealistic demands on all members of the blended family. . . . Between the two opposing myths lies reality. The recognition of reality is, I believe, the most important step toward the building of a successful second family.”
—Claire Berman (20th century)
“Instead of seeing society as a collection of clearly defined “interest groups,” society must be reconceptualized as a complex network of groups of interacting individuals whose membership and communication patterns are seldom confined to one such group alone.”
—Diana Crane (b. 1933)