Members of The Complex
The translocase of the outer membrane (TOM) forms a complex made of Tom70, Tom22, and Tom20, along with Tom40, Tom7, Tom6, and Tom5. Tom20 and Tom22 are preprotein receptors, which are responsible for recognition of the cleavable presequence possessed by mitochondrial-targeted proteins. Tom70 is also a preprotein receptor and may recognise some cleavable presequence proteins, however it is mainly responsible for the recognition of non-cleavable preproteins and acts as a point for chaperone binding. Tom22 is anchored to the outer membrane by a single transmembrane segment and also plays a role in stabilizing the TOM complex. Tom40 is the core element of the translocase complex and complexes with Tom22 with a mass of approximately 350k Daltons. It forms the central protein-conducting channel with a diameter of approximately 2.5 nm. The human Tom22 is approximately 15.5k Daltons and complexes with Tom20. The N-terminal end of Tom22 extends into the cytosol and is involved in preprotein binding.
Read more about this topic: Translocase Of The Outer Membrane
Famous quotes containing the words members of the, members of, members and/or complex:
“Sometimes the best way to keep peace in the family is to keep the members of the family apart for awhile.”
—Franklin D. Roosevelt (1882–1945)
“What’s the greatest enemy of Christianity to-day? Frozen meat. In the past only members of the upper classes were thoroughly sceptical, despairing, negative. Why? Among other reasons, because they were the only people who could afford to eat too much meat. Now there’s cheap Canterbury lamb and Argentine chilled beef. Even the poor can afford to poison themselves into complete scepticism and despair.”
—Aldous Huxley (1894–1963)
“Jesus, Buddha, Mahommed, great as each may be, their highest comfort given to the sorrowful is a cordial introduction into another’s woe. Sorrow’s the great community in which all men born of woman are members at one time or another.”
—Sean O’Casey (1884–1964)
“All of life and human relations have become so incomprehensibly complex that, when you think about it, it becomes terrifying and your heart stands still.”
—Anton Pavlovich Chekhov (1860–1904)