Topsy may refer to:
- Topsy, Oklahoma
- Topsy and Eva (1928 film), a film based on Uncle Tom's Cabin
- Topsy (elephant), a circus animal
- Topsy and Tim, a children's book series
- Mitsubishi Ki-57, an aircraft
- A character in the novel Uncle Tom's Cabin
- A character in the cartoon series Tom and Jerry
- "Topsy" (song), a jazz instrumental first recorded by Benny Goodman and later by Cozy Cole