Side Effects of Topical Steroids
- Diabetes mellitus
- Osteoporosis
- Topical Steroid Withdrawal (TSW)
- Allergic contact dermatitis (see steroid allergy)
- Steroid atrophy
- Perioral dermatitis: This is a rash that occurs around the mouth and the eye region that has been associated with topical steroids.
- Ocular effects: Topical steroid drops are frequently used after eye surgery but can also raise intra-ocular pressure (IOP) and increase the risk of glaucoma, cataract, retinopathy as well as systemic adverse effects.
- Tachyphylaxis: The acute development of tolerance to the action of a drug after repeated doses. Significant tachyphylaxis can occur by day 4 of therapy. Recovery usually occurs after 3 to 4 days rest. This has led to therapies such as 3 days on, 4 days off; or one week on therapy, and one week off therapy.
- Vehicle-related adverse effects
- Other local adverse effects: These include facial hypertrichosis, folliculitis, miliaria, genital ulcers, and granuloma gluteale infantum. Long term use has resulted in Norwegian scabies, Kaposi's sarcoma, and other unusual dermatosis.
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