Tooth Development - Molecular Biology

Molecular Biology

In fish hox gene expression regulates mechanisms for teeth initiation.

In mouse WNT signals are required for the initiation of teeth development.

NGF-R was present in the condensing ecto-mesenchymal cells of the dental papilla in the early cap stage tooth germ and play multiple roles during morphogenetic and cytodifferentiation events in the tooth. There is a relationship between tooth agenesis and absence of the peripheral trigeminal nerve (see Hypodontia).

All stages (bud, cap, bell, crown), growth and morphogenesis of the teeth are regulated by a protein: sonic hedgehog.

During tooth development there are strong similarities between keratinization and amelogenesis. Keratin is also present in epithelial cells of tooth germ and a thin film of keratin is present on the tooth erupted recently (Nasmyth's membrane or enamel cuticle).

Enamel knots as a signaling center in the tooth morphogenesis and odontoblast differentiation.

Various phenotypic inputs modulate the size of the teeth.

The shape of the teeth in prehistoric man was different from that of modern man.

In some dermoid teratomas (particularly ovarian, lung, pancreas, testes) develop complete teeth.

For the tooth eruption is necessary parathyroid hormone.

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