Tompkins is a surname, and may refer to:
- Aaron B. Tompkins (1844-1931), American cavalry soldier and Medal of Honor recipient
- Andrew Tompkins, Australian musician
- Angel Tompkins (b. 1942), American actress
- Anne Tompkins, American lawyer
- Arthur S. Tompkins (1865-1938), U.S. Representative from New York
- Barry Tompkins (born c. 1940), American sportscaster
- Brian Tompkins, Yale Varsity Soccer coach
- Caleb Tompkins (1759-1846), U.S. Representative from New York
- Charles Henry Tompkins (1830-1915), Union Brigadier General during the American Civil War
- Charles Hook Tompkins (1883-1956), American engineer and architect
- Chris Tompkins, American songwriter
- Christopher Tompkins (1780-1858), U.S. Representative from Kentucky
- Cydnor B. Tompkins (1810-1862), U.S. Representative from Ohio
- Daniel D. Tompkins (1775-1824), American Vice-President
- Darlene Tompkins (b. 1940), American actress
- Douglas Tompkins (b. 1943), American environmentalist, co-founder of outdoor clothing companies, owner of Pumalín Park, Chile
- Emmett Tompkins (1853-1917), U.S. Representative from Ohio
- Fred Tompkins (b. 1943), American jazz flautist
- Gwyn R. Tompkins (1861-1938), American horse racing trainer
- Hannah Tompkins (1721-1829), wife of Daniel D. Tompkins
- Hannah Tompkins (artist) (1920-1995), American artist
- Jack Tompkins (1909-1993), American baseball and ice hockey player
- James Tompkins (1870-1953), Canadian activist priest
- Jason Tompkins, British actor
- Jessie Tompkins (b. 1959), former American athlete
- Joan Tompkins (1915-2005), American actress
- Joe Tompkins (b. 1968), American professional skier
- Kris Tompkins (b. 1950), American conservationist
- Larry Tompkins (b. 1963), retired Irish Gaelic football manager
- Lee Tompkins (b; 1963), American artist
- Madeline Tompkins (b. 1952), American airline pilot, co-pilot Aloha Airlines flight 243
- Mike Tompkins (b. 1948), U.S. politician
- Minthorne Tompkins (1807–1881), New York politician
- Oscar Tompkins (1893-1969), American lawyer
- Patrick W. Tompkins (?-1853), U.S. Representative from Mississippi
- Paul F. Tompkins (b. 1968), American actor and comedian
- Pauline Tompkins (d. 2004), American educator
- Peter Tompkins (1919-2007), American journalist
- Ptolemy Tompkins, American writer
- Richard Tompkins (1918-1992), American entrepreneur
- Roger Tompkins (b. 1952), British television commercial director
- Ross Tompkins (1938-2006), American jazz pianist
- Sally Louisa Tompkins (1833-1916), American humanitarian, nurse and philanthropist
- Shawn Tompkins, Canadian former martial arts fighter
- Stephen Tompkins (b. 1971), American artist and animator
- Steve Tompkins, American television writer
- Sue Tompkins (b. 1971), British visual and sound artist
- Timothy Tompkins, American artist
- Tony Tompkins (b. 1982), Canadian football player
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