Isoforms
A number of titin isoforms are produced in different striated muscle tissues as a result of alternative splicing. All but one of these isoforms are in the range of ~27,000 to ~33,000 amino acid residues in length. The exception is the small cardiac novex-3 isoform which is only 5,604 amino acid residues in length. The following table lists the known titin isoforms:
| Isoform | alias/description | length | MW |
|---|---|---|---|
| Q8WZ42-1 | the "canonical" full length sequence | 34,350 | 3,816,030 |
| Q8WZ42-2 | 34,258 | 3,805,708 | |
| Q8WZ42-3 | small cardiac N2-B | 26,926 | 2,992,939 |
| Q8WZ42-4 | soleus | 33,445 | 3,716,027 |
| Q8WZ42-5 | 32,900 | 3,653,085 | |
| Q8WZ42-6 | small cardiac novex-3, phosphorylated on Thr-5304 and Ser-5306. |
5,604 | 631,567 |
| Q8WZ42-7 | cardiac novex-2 | 27,118 | 3,734,648 |
| Q8WZ42-8 | cardiac novex-1 | 27,051 | 3,829,846 |
| Q8WZ42-9 | 27,118 | 3,013,957 | |
| Q8WZ42-10 | 27,051 | 3,006,755 | |
| Q8WZ42-11 | 33,423 | 3,713,600 |
Read more about this topic: Titin