Tighe may refer to:
- Tadhg, given name
- Tighe, California, former name of Burlington, California
- people with the given name Tighe
- Tighe Dombrowski (1982- ), American soccer player
- Tighe Scott (1949- ), American racecar driver
- people with the surname Tighe
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- Pronounced /ˈtaɪ/, seldom /ˈtaɪɡ/, /ˈtiːɡ/, etc.
- Ambrose Tighe (1859–1928), American lawyer, politician, and academic
- Andrew Tighe, Australian actor
- Brad Tighe (1984- ), Australian rugby league player
- Darren Tighe, English actor and comedian
- Lieutenant General Eugene F. Tighe, director of the U.S. Defense Intelligence Agency
- Jack Tighe (1913–2002), American baseball manager
- James Tighe, British professional wrestler
- Karen Tighe, Australian radio and television sports presenter
- Kevin Tighe (1944- ), American actor
- Mary Tighe (1772–1810), Irish poet
- Michael Tighe, American musician and actor
- Robert Tighe (????-1620), English cleric and
- Tommy Tighe, sports radio broadcaster