List of Tumors and Entrance of A Tumor Type Into TCGA
A preliminary list of tumors for TCGA to study was generated by compiling incidence and survival statistics from the SEER Cancer Statistic website (http://seer.cancer.gov/). In addition, U.S. current “Standard of Care” was considered when choosing the top 25 tumor types, as TCGA is targeting tumor types where resection prior to adjunct therapy is the standard of care. Availability of samples also plays a critical role in determining which tumor types to study and the order in which tumor projects are started. The more common the tumor is, the more likely that samples will be accrued quickly, resulting in common tumor types, such as colon, lung and breast cancer becoming the first tumor types entered into the project, before rare tumor types.
TCGA Targeted Tumors: Lung squamous cell carcinoma, kidney papillary carcinoma, clear cell kidney carcinoma, breast ductal carcinoma, diffuse large B-cell lymphoma, renal cell carcinoma, Cervical Cancer (squamous), Colon adenocarcinoma, stomach adenocarcinoma, rectal carcinoma, hepatocellular carcinoma, Astrocytoma, Head and neck (oral) squamous cell carcinoma, Thyroid carcinoma, Bladder urothelial carcinoma - nonpapillary, uterine Corpus (endometrial carcinoma), invasive urothelial bladder cancer, Pancreatic ductal adenocarcinoma, acute myeloid leukemia, prostate adenocarcinoma,lung adenocarcinoma, cutaneous melanoma, breast lobular carcinoma and multiple myeloma.
TCGA is accruing samples for all of these tumor types simultaneously. As samples become available, the tumor types with the most samples accrued will be entered into production. For more rare tumor types, tumor types where samples are difficult to accrue and for tumor types where TCGA cannot identify a source of high quality samples, these types of cancer will enter the “TCGA production pipeline” in the second year of the project. This will give the TCGA Program Office additional time to accrue sufficient samples for the project. If TCGA plans to characterized 20 tumor types in five years and there are 25 potential tumor types on the list, obviously, five types of cancer will not be studied unless additional funds are made available.
TCGA is currently utilizing ARRA funding to accrue both retrospectively and prospectively collected cases.
Read more about this topic: The Cancer Genome Atlas
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