TCR may refer to:
- Time Code Reading, a method of accounting for video or film footage and frames in media editing
- T-cell receptor, is a molecule found on the surface of T lymphocytes that is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules
- Technical Certification Requirements, standards that a video game must satisfy in order to be distributed on a given platform
- Toronto Civic Railways
- Total Control Racing, a slotless track mini-car racing that lets you control your car
- Total Core Recovery, an expression used for qualifying the quality of a rock mass in boreholes
- Tottenham Court Road, a street in London which Tottenham Court Road tube station is named after
- TCR, the musical project of Robin Moulder and TC of Satiate
- A single by the band Prolapse
- A joint venture between Brambles Industries and German airport company Fraport AG
- Transmission Control Room is a room found at broadcast facilities and television stations around the world
- Transcription-coupled repair a DNA repair mechanism
- The Colbert Report, a parody news show on Comedy Central
- The Climate Registry, a nonprofit collaboration to record and track greenhouse gas emissions
- Thyroid Cartilage Reduction (Chondrolaryngoplasty)
- TCR (record label), a record label
- Temperature Coefficient of Resistance, typically measured in "ppm/K"
- Thyristor Controlled Reactor
- Text Compression for Reader (.tcr), a compressed text file format used by Psion e-book reader software
- Tuticorin Airport, IATA code TCR
- Teller Cash Recycler: A cash automation device proven to improve financial institutions' efficiency with cash transactions
- The Composing Rooms, a gallery based in London and Berlin