Tarrasch Defense
In the main line, White will isolate Black's queen pawn with 4. cxd5 exd5 and attempt to exploit its weakness. The most common setup is to fianchetto his king's bishop in order to put pressure on the isolated d5-pawn, as 3...c5 has relinquished the possibility of protecting the point d5 by means of ...c6.
After 4.cxd5, Black may offer the Hennig-Schara Gambit with 4...cxd4. While this was once essayed by Alekhine, it has never achieved popularity at master level and is considered good for White.
On his third move White often plays 3.Nf3 instead (in part to avoid the Hennig-Schara), which after 3...c5 4.cxd5 exd5 5.Nc3 transposes to the main line.
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