Sweetser may refer to:
- Charles H. Sweetser (1841–1871), author and journalist
- Charles Sweetser (1808–1864), politician
- Eve Sweetser, linguist
- Jess Sweetser (1902–1989), amateur golfer
- Kate Dickinson Sweetser (?-1939), fiction author
- Lewis H. Sweetser, politician
- Wesley D. Sweetser (1919–2006), critic