Regions
The genome is functionally divided into 3 regions:
- Early: Expressed early in virus infection, i.e. BEFORE genome replication. Expression of early genes continues during the late stage of infection. Encodes non-structural proteins (i.e. not present in virus particle).
- Late: Expressed later in virus infection, i.e. DURING & AFTER genome replication. Encodes structural proteins (i.e. present in virus particle).
- Regulatory region: Contains transcriptional promoters & enhancers plus the unique origin of DNA replication.
Read more about this topic: SV40 Large T-antigen
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