Surrogate Endpoint - Criticism

Criticism

There have been a number of instances when studies using surrogate markers have been used to show benefit from a particular treatment, but later, a repeat study looking at endpoints has not shown a benefit, or even a harm.

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Famous quotes containing the word criticism:

    I hold with the old-fashioned criticism that Browning is not really a poet, that he has all the gifts but the one needful and the pearls without the string; rather one should say raw nuggets and rough diamonds.
    Gerard Manley Hopkins (1844–1889)

    ... criticism ... makes very little dent upon me, unless I think there is some real justification and something should be done.
    Eleanor Roosevelt (1884–1962)

    However intense my experience, I am conscious of the presence and criticism of a part of me, which, as it were, is not a part of me, but a spectator, sharing no experience, but taking note of it, and that is no more I than it is you. When the play, it may be the tragedy, of life is over, the spectator goes his way. It was a kind of fiction, a work of the imagination only, so far as he was concerned.
    Henry David Thoreau (1817–1862)