Examples
What are the causes of an acute confusional state in a patient?
- Idiopathic/Iatrogenic: polypharmacy, sedatives, analgesics, steroids, drug withdrawal
- Vascular: stroke, TIA, vascular dementia
- Inflammatory: infection, systemic inflammatory response syndrome
- Traumatic: head injury, Intracranial hemorrhage, shock
- Autoimmune: thyroid disease
- Metabolic: electrolyte imbalance, DKA, hypoglycaemia, SIADH
- Infective: sepsis, local infection
- Neoplastic: brain tumour, carcinomatosis
- Degenerative: Alzheimer's Disease, dementia
What are the causes of splenomegaly?
- Idiopathic: Idiopathic thrombocytopenic purpura
- Vascular: portal vein obstruction, Budd-Chiari syndrome, haemoglobinopathies (Sickle-cell disease, thalassemia)
- Infective: AIDS, mononucleosis, septicaemia, tuberculosis, brucellosis, malaria, infective endocarditis
- Traumatic: haematoma, rupture
- Autoimmune: rheumatoid arthritis, SLE
- Metabolic: Gaucher's disease, mucopolysaccharidoses, amyloidosis, Tangier disease
- Inflammatory: sarcoidosis
- Neoplastic: CML, metastases, myeloproliferative disorders
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