Human
Three forms of superoxide dismutase are present in humans, in all other mammals, and most chordates. SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. The first is a dimer (consists of two units), whereas the others are tetramers (four subunits). SOD1 and SOD3 contain copper and zinc, whereas SOD2, the mitochondrial enzyme, has manganese in its reactive centre. The genes are located on chromosomes 21, 6, and 4, respectively (21q22.1, 6q25.3 and 4p15.3-p15.1).
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Read more about this topic: Superoxide Dismutase, Types
Famous quotes containing the word human:
“The human head is bigger than the globe. It conceives itself as containing more. It can think and rethink itself and ourselves from any desired point outside the gravitational pull of the earth. It starts by writing one thing and later reads itself as something else. The human head is monstrous.”
—Günther Grass (b. 1927)
“As I look at the human story I see two stories. They run parallel and never meet. One is of people who live, as they can or must, the events that arrive; the other is of people who live, as they intend, the events they create.”
—Margaret Anderson (1886–1973)
“When superstition is allowed to perform the task of old age in dulling the human temperament, we can say goodbye to all excellence in poetry, in painting, and in music.”
—Denis Diderot (1713–1784)