Human
Three forms of superoxide dismutase are present in humans, in all other mammals, and most chordates. SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. The first is a dimer (consists of two units), whereas the others are tetramers (four subunits). SOD1 and SOD3 contain copper and zinc, whereas SOD2, the mitochondrial enzyme, has manganese in its reactive centre. The genes are located on chromosomes 21, 6, and 4, respectively (21q22.1, 6q25.3 and 4p15.3-p15.1).
|
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Read more about this topic: Superoxide Dismutase, Types
Famous quotes containing the word human:
“Translation is the paradigm, the exemplar of all writing.... It is translation that demonstrates most vividly the yearning for transformation that underlies every act involving speech, that supremely human gift.”
—Harry Mathews (b. 1930)
“It is open to question whether the highly individualized characters we find in Shakespeare are perhaps not detrimental to the dramatic effect. The human being disappears to the same degree as the individual emerges.”
—Franz Grillparzer (1791–1872)
“To see self-sufficiency as the hallmark of maturity conveys a view of adult life that is at odds with the human condition, a view that cannot sustain the kinds of long-term commitments and involvements with other people that are necessary for raising and educating a child or for citizenship in a democratic society.”
—Carol Gilligan (20th century)