Failure
The Strategies for the Management of Antiretroviral Therapy (SMART) trial was intended to provide good information on whether this approach worked for HIV+ people. The double-blind controlled study began in 2002 and enrolled 5,472 participants in 33 countries. Unfortunately for proponents of SIT, the study had to be stopped in 2006 because of the excessive number of "interrupted" patients who died or got much sicker. People on the SIT protocol were more than twice as likely to die during the study than people who took HAART drugs continuously.
Read more about this topic: Structured Intermittent Therapy
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