Stromal Cell-derived Factor-1

Stromal Cell-derived Factor-1

Identifiers Symbols CXCL12; IRH; PBSF; SCYB12; SDF1; SDF1A; SDF1B; TLSF; TPAR1 External IDs OMIM: 600835 MGI: 103556 HomoloGene: 128606 GeneCards: CXCL12 Gene

Gene Ontology
Molecular function	• receptor binding • chemokine activity • growth factor activity • CXCR chemokine receptor binding
Cellular component	• extracellular region • extracellular space • external side of plasma membrane
Biological process	• patterning of blood vessels • response to hypoxia • ameboidal cell migration • neuron migration • positive regulation of endothelial cell proliferation • cellular calcium ion homeostasis • chemotaxis • immune response • cell adhesion • signal transduction • G-protein coupled receptor signaling pathway • germ cell development • blood circulation • motor neuron axon guidance • regulation of actin polymerization or depolymerization • adult locomotory behavior • germ cell migration • response to radiation • response to heat • response to mechanical stimulus • response to virus • telencephalon cell migration • organ regeneration • positive regulation of dopamine secretion • T cell proliferation • negative regulation of apoptotic process • response to peptide hormone stimulus • positive regulation of neuron differentiation • positive regulation of axon extension involved in axon guidance • induction of positive chemotaxis • chemokine-mediated signaling pathway • positive regulation of monocyte chemotaxis • negative regulation of leukocyte apoptotic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6387 20315 Ensembl ENSG00000107562 ENSMUSG00000061353 UniProt P48061 P40224 RefSeq (mRNA) NM_000609.5 NM_001012477.2 RefSeq (protein) NP_000600.1 NP_001012495.1 Location (UCSC) Chr 10:
44.79 – 44.88 Mb Chr 6:
117.12 – 117.13 Mb PubMed search

SDF-1 (stromal cell-derived factor-1) is small cytokine belonging to the chemokine family that is officially designated Chemokine (C-X-C motif) ligand 12 (CXCL12).

Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. The intercrines are characterized by the presence of 4 conserved cysteines that form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group.