Stewie Kills Lois and Lois Kills Stewie - Production

Production

"Stewie Kills Lois" and "Lois Kills Stewie" are the 102nd and 103rd episodes of Family Guy respectively. They are the fourth and fifth episodes of the sixth season of the show. "Stewie Kills Lois" was written by executive producer and former Futurama and South Park writer David A. Goodman. The episode was directed by John Holmquist. "Lois Kills Stewie" was written by recurring voice actor and future showrunner Steve Callaghan, and directed by Greg Colton. Colton and Callaghan previously worked on the season 5 episode "Whistle While Your Wife Works".

Before the airing of the episode, a 100th episode tribute special, hosted by MacFarlane, aired on Fox. The special showcases various clips of MacFarlane's favorite moments from the last 99 episodes of the show. It also included MacFarlane asking people questions related to Family Guy.

"Stewie Kills Lois" and "Lois Kills Stewie", along with the final five episodes of the fifth season and the first seven episodes of the sixth season, were also released on DVD under the title "Volume 6" by 20th Century Fox in the United States and Canada on October 21, 2008, five months after they had completed broadcast on television. The DVD release also features bonus material including deleted scenes, commentaries, and a 'making of' feature.

Both episodes aired before the 2007–2008 Writers Guild of America strike, and were the last episodes to air before it. In November 2007, Variety reported that MacFarlane had joined the strike and refused to complete more Family Guy episodes. A spokesperson for Fox said: "Our hope is that he returns to work and completes his non-writing obligations on those episodes". Fox aired two new episodes during November 2007. The following episode, "Padre de Familia", was the first of these two episodes to air. The strike ended on February 12, 2008 and the series resumed airing regularly.

In addition to the main cast, actors Patrick Stewart and Phil LaMarr, and American Idol judges Simon Cowell, Randy Jackson and Paula Abdul guest starred in the episode. The episode also featured the recurring voices of actress Jennifer Tilly and Patrick Warburton, and writers Danny Smith and John Viener in minor appearances. Future showrunner Mark Hentemann also made some appearances.

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