STAT Family
The first two STAT proteins were identified in the interferon system. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are involved in type II interferon signalling, and bind to the GAS (Interferon-Gamma Activated Sequence) promoter to induce expression of ISG (Interferon Stimulated Genes). In type I interferon signaling, STAT1-STAT2 heterodimer combines with IRF9 (Interferon Response Factor) to form ISGF3 (Interferon Stimulated Gene Factor), which binds to the ISRE (Interferon Stimulated Response Element) promoter to induce ISG expression.
Read more about this topic: STAT Protein
Famous quotes containing the word family:
“Being in a family is like being in a play. Each birth order position is like a different part in a play, with distinct and separate characteristics for each part. Therefore, if one sibling has already filled a part, such as the good child, other siblings may feel they have to find other parts to play, such as rebellious child, academic child, athletic child, social child, and so on.”
—Jane Nelson (20th century)