Src (gene)

Src (gene)

Identifiers Symbols SRC; ASV; SRC1; c-SRC; p60-Src External IDs OMIM: 190090 MGI: 98397 HomoloGene: 21120 ChEMBL: 267 GeneCards: SRC Gene EC number 2.7.10.2

Gene Ontology
Molecular function	• protein kinase activity • protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • SH3/SH2 adaptor activity • receptor binding • integrin binding • protein binding • ATP binding • kinase activity • heme binding • SH2 domain binding • ion channel binding • ephrin receptor binding
Cellular component	• nucleus • mitochondrial inner membrane • lysosome • late endosome • cytosol • cytoskeleton • plasma membrane • caveola
Biological process	• cell cycle • cell adhesion • signal transduction • signal complex assembly • epidermal growth factor receptor signaling pathway • intracellular protein kinase cascade • Ras protein signal transduction • axon guidance • blood coagulation • fibroblast growth factor receptor signaling pathway • cellular membrane organization • peptidyl-tyrosine phosphorylation • virus-host interaction • platelet activation • forebrain development • T cell costimulation • regulation of intracellular estrogen receptor signaling pathway • positive regulation of integrin activation • regulation of vascular permeability • regulation of bone resorption • bone resorption • nerve growth factor receptor signaling pathway • oogenesis • progesterone receptor signaling pathway • leukocyte migration • negative regulation of focal adhesion assembly • uterus development • branching involved in mammary gland duct morphogenesis • response to interleukin-1 • cellular response to progesterone stimulus • positive regulation of canonical Wnt receptor signaling pathway • negative regulation of anoikis • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of intrinsic apoptotic signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6714 20779 Ensembl ENSG00000197122 ENSMUSG00000027646 UniProt P12931 P05480 RefSeq (mRNA) NM_005417.3 NM_001025395.2 RefSeq (protein) NP_005408.1 NP_001020566.1 Location (UCSC) Chr 20:
35.97 – 36.03 Mb Chr 2:
157.42 – 157.47 Mb PubMed search

Proto-oncogene tyrosine-protein kinase Src is an enzyme that in humans is encoded by the SRC gene.

Src (pronounced "sarc" as it is short for sarcoma) is a proto-oncogene encoding a tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus, for which they were awarded the 1989 Nobel Prize in Physiology or Medicine. It belongs to a family of non-receptor tyrosine kinases called Src family kinases. The discovery of Src family proteins has been instrumental to the modern understanding of cancer as a disease where normally healthy cellular signalling has gone awry.

This gene is similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.