SPT may refer to:
- Organizations
- Sony Pictures Television, American television company
- Strathclyde Partnership for Transport, organization which plans public transport
- SPTrans, a large urban public transport authority in São Paulo, Brazil
- St. Paul Travelers Companies, predecessor of The Travelers Companies insurance
- Science
- Shortest path tree, type of graph
- Skin prick test, allergy test
- Standard penetration test, to measure the properties of soil
- Serine C-palmitoyltransferase, an enzyme catalyst
- Single Particle Tracking, a method for measuring particle diffusion
- South Pole Telescope, telescope located at an Antarctic research station
- Stationary Plasma Thruster, a type of hall effect thruster for spacecraft propulsion developed in the Soviet Union
- Fiction
- Blue Comet SPT Layzner, a Japanese animation television and OAV series
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- Super Powered Tracer from the anime SPT Layzner
- Other uses
- Space Preservation Treaty, proposed international treaty to ban weapons
- Southport, a town in Northwest England
- Shortest processing time, heuristics term
- Spt function, a function in mathematics that counts the number of smallest parts in a partition